Results 71 to 80 of about 5,587,139 (296)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Índices de impacto cultural: antecedentes, metodología y resultados

, 2014
El resultado que se registra en el presente documento es un hallazgo metodológico para la definición de una batería de indicadores de efecto e impacto cultural y para la construcción de índices de impacto cultural.
Banco de la República (Bogotá). Subgerencia Cultural
core  

S'Esclop. Quadern cultural 2009, no. 46 [PDF]

, 2009
not ...
Esclop Associació Cultural
core  

Patients as teachers: a qualitative study of spiritual care delivery experiences of senior healthcare providers in Taiwan

BMC Medical Education
Background Spiritual care is a core component of holistic health care that addresses patients’ existential and emotional needs. However, in Taiwan, spiritual care delivery remains inconsistent due to cultural, educational, and institutional barriers ...
Hsiao-Fen Lo, Jaw-Shiun Tsai, Chen-Yin Tung, Chia-Chen Chang   +3 more
doaj   +1 more source

Cultivating Language Learning Through Cultural Sensitivity and Empathy. An e-Tandem Case Study of Mexican and Canadian Students

Revista Lengua y Cultura
This article examines how cultural sensibility and empathy towards the interlocutor foster language learning and intercultural competence. We analyzed the results of an e-Tandem program conducted between a private high school in Vancouver, Canada, and a ...
Raquel Acosta Fuentes, Andrea A. Valdiri Suesca   +1 more
doaj   +1 more source

Managing the Needs of Orphans and Vulnerable Children in Mainstream Rural Schools: An Ethnopsychology Informed Approach [PDF]

E-Journal of Humanities, Arts and Social Sciences
Orphans and vulnerable children (OVC) in mainstream rural schools encounter unique challenges stemming from loss, economic instability, and disrupted familial structures.
Nowell Chidakwa, Fumane Portia Khanare
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

S'Esclop. Quadern cultural 2010, no. 52 [PDF]

, 2010
not ...
Esclop Associació Cultural
core  

Culture and Behaviour Management of Children in the Dental Clinic: A Scoping Review

Dentistry Journal
Cultural norms, beliefs, and practices influence parental expectations, children’s responses, and the acceptance of behaviour management techniques (BMTs) in paediatric dentistry. Despite this, the existing guidelines often adopt a standardized approach,
Adebola Oluyemisi Ehizele, Love Bukola Ayamolowo, Adeyinka Ishola, Moréniké Oluwátóyìn Foláyan   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source