Results 71 to 80 of about 871,084 (301)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

[Review of] Thomas Kochman, Black and White Styles in Conflict [PDF]

open access: yes, 1983
Race, class and culture are the ingredients of black-white relations in America. Thomas Kochman\u27s book attempts to separate out the cultural component of this mix and to examine it because he believes that it is both ignored and the source of much ...
Traynham, Warner R.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Paper III: bi-cultural use of Kaiawhina: cultural sensitivity or conflict? [PDF]

open access: yes, 2016
In an earlier paper (TeApatu et al., 2014) it was argued that researching issues of interest to Maori or indigenous populations must be relevant and culturally sensitive.
Liddell, Jan   +2 more
core  

The expatriate library director [PDF]

open access: yes, 2007
Purpose - The purpose of this paper is to provide library managers with information about what to expect if they are considering a post in another country. It challenges a suggestion that a senior manager's major value is their local network. Rather, the
McKnight, S
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Cultivating Language Learning Through Cultural Sensitivity and Empathy. An e-Tandem Case Study of Mexican and Canadian Students

open access: yesRevista Lengua y Cultura
This article examines how cultural sensibility and empathy towards the interlocutor foster language learning and intercultural competence. We analyzed the results of an e-Tandem program conducted between a private high school in Vancouver, Canada, and a ...
Raquel Acosta Fuentes   +1 more
doaj   +1 more source

Managing the Needs of Orphans and Vulnerable Children in Mainstream Rural Schools: An Ethnopsychology Informed Approach [PDF]

open access: yesE-Journal of Humanities, Arts and Social Sciences
Orphans and vulnerable children (OVC) in mainstream rural schools encounter unique challenges stemming from loss, economic instability, and disrupted familial structures.
Nowell Chidakwa, Fumane Portia Khanare
doaj   +1 more source

Measuring intercultural sensitivity in different cultural context [PDF]

open access: yes, 2000
As a main dimension of intercultural communication competence, intercultural sensitivity has increasingly gained attention in research in different disciplines.
Chen, Guo-Ming   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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