Results 41 to 50 of about 4,263,874 (300)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Psychopathology and Depression in the Middle East
Psychiatry and Behavioral Sciences, 2012 Psychotherapy methods are mostly constructed by the Western societies and thus they might fail to address the social and cultural differences of other, non-Western societies.
Kemal Sayar, Samet Kose
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
FROM MULTICULTURALISM TO INTERCULTURATION [PDF]
Social Sciences and Education Research Review, 2020 Due to the dynamism and heterogeneity specific to most societies nowadays, cultural diversity is a constant of social life. Therefore, different cultural identities, cultural contacts and exchanges, interculturality, but also subcultures and ...
Simona RODAT
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MST Review, 2020 This paper deals with how society and culture may shape us; how some sub-cultures may shape ‘others’; how we behave and embody our own worlds replete with models for imitation. Despite this socio-cultural determination, it is assumed in this study that in the process of formation, choice is possible; and that choice is limited.
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Exploitation des invertébrés par les sociétés précolombiennes des Petites Antilles
Journal de la Société des Américanistes, 2007 Exploitation of invertebrates by the Precolumbian societies of the Lesser Antilles. Invertebrates (molluscs and crustaceans) were significant resources for the Precolumbian societies present in the West Indian islands between the VIth millenium B.C.
Nathalie Serrand
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source