Results 141 to 150 of about 16,073,342 (314)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Assignments - A Cultural Awakening at the BCC

open access: yes, 2013
6th Annual Cultural Arts Festival commemorating the 10th anniversary of the BCC.Front page cover of the program containing a list of activities scheduled for the commemorative celebration.No ...
Purdue University Black Cultural Center
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

“Cultural studies in Illiberal Times.”

open access: yes, 2016
This talk will provide a synopsis of my forthcoming book, Illiberal China: The PRC as Ideological Challenge (2017), but with an added emphasis on the state of cultural studies in Hong Kong and as best as I can tell, in China and socalled greater China ...
Vukovich, DF
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Communication and Critical/Cultural Studies

open access: yes
Communication and Critical/Cultural Studies (CC/CS) is a peer-reviewed publication of the National Communication Association. CC/CS publishes original scholarship that situates culture as a site of struggle and communication as an enactment and ...
AIELLO, GIORGIA
core   +1 more source

Trainers : the worlds at our feet and the multiple investments in high performance shoe technology

open access: yes, 2006
The last three decades in sports-shoes and trainer design has witnessed the humble sneaker transformed into the performance enhancing equipment of the professional sporting elite. The rhetoric of trainer manufacturers tells us that the features developed
Gill, Alison (R7721)
core  

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