Results 81 to 90 of about 568,991 (294)

Cumulative Effect in Culture: Old Germanic Culture

СибСкрипт
The cumulative effect in culture is a mechanism that protects traditional elements from sociocultural changes. To analyze the stability of archaic forms within cultural dynamics, the author developed a methodological model for analyzing the cumulative ...
Maxim A. Schegolev
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Extensive Semantic Design Approach for Cultural and Creative Products of Traditional Patterns in China: A Case Study of Panhu Pattern in She Nationality

SAGE Open
Traditional patterns are enriched with unique ethnic and artistic significance and serve as a valuable inspiration for creating culturally innovative products.
Ruizhi Zhang, Li Jiang, Zhouxu Zhang, Minsun Sung   +3 more
doaj   +1 more source

AN EXAMINATION OF MEDIA CONVERGENCE AND ITS IMPLICATION ON MASS COMMUNICATION NOTION

Journal Communication Spectrum, 2011
Mass communication, which has created media effect theory and cultural study as well as critical theory during its development, cannot be separated from its massive extend manner towards the public that could influence individuals, community, and ...
Bintang Handayani
doaj   +1 more source

Community Service-Learning and Cultural-Historical Activity Theory

, 2014
This paper explores the potential of cultural-historical activity theory (CHAT), to provide new insights into community service-learning (CSL) in higher education.
Alison Taylor
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Chinese Neologisms and Metaphorical Potential in Pedagogy

Annali di Ca’ Foscari: Serie Orientale
Neologisms are a group of words that have undergone a significant transformation from top-down dissemination to a more horizontal, grassroots-driven spread, particularly fuelled by the rise of the Internet and computer-mediated communication.
Gebbia, Claudio
doaj   +1 more source

The femme factor: Transforming pop culture analyses through femme theory

Sexualities
Scanning the indices of popular culture textbooks reveals an asymmetry: numerous entries on masculinities but not a single femininities entry. What does this asymmetry say about gender theory and, more specifically, femininity? While feminist theorists have produced important scholarship illuminating femininity as a patriarchal tool wielded through ...
Rhea Ashley Hoskin, Karen Blair
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source