Results 51 to 60 of about 518,211 (354)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

How pain becomes common? Cultural trauma as a process

open access: yesStudia Humanitatis, 2018
The article reviews the process and peculiarities of the transition of personal trauma into cultural one. The diaries of inhabitants of the besieged Leningrad became the source for the research.
Golovashina Oksana Vladimirovna
doaj  

Re-framing the Spanish Civil War as ‘Cultural Trauma’: When Responsibilities Get Blurred After Violence [PDF]

open access: yesUniversity of Bucharest Review. Literary and Cultural Studies Series, 2019
The aim of this article is to address to what extent some institutional form of remembering the Spanish Civil War (1936-1939) as a collective trauma could be considered an instance of Jeffrey Alexander and Neil Smelzer´s notion of ’cultural trauma ...
Rafael Pérez Baquero
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Displaced Borders: The Written Traumatic Borderline between Pskov Province and Chechnya

open access: yesCulture Unbound: Journal of Current Cultural Research, 2014
This article examines the narrative construction of borders through an analysis of "non-professional writing" produced by the residents of Pskov. It discusses the construction of national borders and the symbolic meanings invested in them, with the ...
Mari Ristolainen
doaj   +2 more sources

Political Youth Organisations, Music and National Identity in Contemporary Russia

open access: yesStudies of Transition States and Societies, 2014
This article analyses the relationship between political youth organisations, music and national identity in contemporary Russia. It focuses on four of the most representative political youth groups present in the city of St. Petersburg – the Young Guard,
Chiara Pierobon
doaj  

From the war in youth to the trauma of defeat, repression and exile. Images and discourses of Spanish Republican aviation

open access: yesCogent Arts & Humanities
The Spanish Civil War (1936-1939) was a cruel confrontation whose consequences were aggravated by Franco’s repression. One army corps that represents the suffering and, at the same time, the will for individual and collective recovery at its best is the ...
Carmen Marimón Llorca   +1 more
doaj   +1 more source

The weight of the past: trauma and testimony in Que bom te ver viva [PDF]

open access: yes, 2015
This article examines representations of trauma in Lúcia Murat’s Que bom te ver viva (How Nice to See You Alive, 1989), a semi-documentary focusing on the experiences of former political militants who, like the director herself, were arrested and ...
Heise, Tatiana
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Czarne cierpienie, dekontekstualizacja i problemy współczesnego horroru rasowego

open access: yesStudia Filmoznawcze
This article examines the problematic issues surrounding horror films that have addressed race since the release of Get Out. The article outlines the significance of Jordan Peele’s feature film debut, considering context of black horror, as well as the ...
Dominik Langiewicz
doaj   +1 more source

Home - About - Disclaimer - Privacy