Results 91 to 100 of about 2,786,693 (306)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Development, measurement, and managerial implications of Chinese values

open access: yesCogent Social Sciences, 2019
This study contributes to the literature by exploring the research gap for a need to better understand what Chinese values are and how they are to be measured. This study used a summative content analysis approach to develop Chinese values.
Cheng-Liang Yang
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

TEENAGERS CULTURAL VALUES TOWARDS THEIR VERNACULAR AND INDONESIAN LANGUAGES

open access: yesLanguage Literacy: Journal of Linguistics, Literature, and Language Teaching, 2018
This research is aimed at analysing the teenagers’ cultural values towards their vernacular and Indonesian languages. The populations of this research are teenagers around Langsa, especially in old sub district of Langsa named Meurandeh village. They are
Anjasmara Tri Dharma   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

AFRICAN CULTURE AND VALUES

open access: yesPhronimon, 2018
The main objective of this paper is to examine African culture and values. Since culture is often seen as the sum total of the peculiarities shared by a people, a people’s values can be seen as part of their culture. In discussing African culture and values, we are not presupposing that all African societies have the same explanation(s) for events ...
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

UNSUR-UNSUR BUDAYA DALAM AMTSÂL ’ARABIYYAH (PERIBAHASA ARAB)

open access: yesArabiyat, 2014
This article analyze the cultural values in proverb of Arabic (amtsal). The analysis of Amtsal are from the history of ancient Arabian. The results shows that Amtsal reflect cultural values such as; culture, life style, mindset, geography position, and ...
Siti Mahwiyah
doaj   +1 more source

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