Results 71 to 80 of about 17,762,594 (353)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

PROSPECTIVE LEADERS' VIEW ON ROMANIAN SOCIETAL CULTURE [PDF]

open access: yesAnnals of the University of Oradea: Economic Science, 2010
This study deals with Romanian prospective leaders’ perceptions and expectations concerning the societal culture. It is a part of a European research project, GLOBE Students, dealing with the interrelations between societal culture and leadership.
CATANA GHEORGHE ALEXANDRU, CATANA DOINA
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The Image of Public Relations in Indonesian 2001: Myth and Reality in Multicultural Approach [PDF]

open access: yes, 2001
In global environment, understanding and managing multiculturalism mean recognizing similarities and differences among various cultures and use this cultural diversity to achieve one\u27s goal.
Winangsih, N. (Nina)
core   +1 more source

Research note: Measuring cultural values - The case of residents' attitudes to the Saltaire Festival [PDF]

open access: yes, 2006
This research note discusses the findings and methodological issues arising from a cultural values survey of residents, particularly in relation to civic pride.
Bearden W.O.   +4 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Religious values of the IT man

open access: yesJournal of Modern Science
Objectives The aim of the work is to look at the spiritual aspect of human life in the era of computerization of life, which is certainly one of the greatest achievements of human reason; which brings about a breakthrough in the lives of individuals and ...
Piotr Wacław Krajewski, Anna Krajewska
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Does Cultural Heritage Affect Job Satisfaction: The Divide between EU and Eastern Economies [PDF]

open access: yes, 2011
The objective of this paper is to examine the factors influencing worker’s job satisfaction aside the conventional factors (personal background, individual labour market characteristics, organisational culture, and so on) and introduce the basic cultural
Mojsoska-Blazevski, Nikica   +1 more
core   +1 more source

Climate adaptation strategies in Fiji: The role of social norms and cultural values

open access: yesWorld Development, 2018
The Fiji Islands in the South Pacific are highly exposed to climate-induced hazards and have experienced several flood and cyclone events in recent years.
A. Neef   +5 more
semanticscholar   +1 more source

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