Results 121 to 130 of about 2,133,258 (309)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluation of MODS Culture in the Diagnosis of Pulmonary Tuberculosis

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and Objectives Culture of M. tuberculosis is the golden standard for the diagnosis of TB which is a much more sensitive test than Smear examination. There is a strong need to use the new assays in order to speed up diagnostic methods.
Z Aminzadeh, F Fallah, B Manafian, P Baghaei   +3 more
doaj  

In search of the best method to detect carriage of carbapenem-resistant Pseudomonas aeruginosa in humans: a systematic review

Annals of Clinical Microbiology and Antimicrobials
Background Detection of carbapenem-resistant Pseudomonas aeruginosa (CR-PA) in humans is important to prevent transmission. However, the most optimal culture method to detect CR-PA is unknown. This systematic review aims to determine which culture method
Selvi N. Shahab, Anneloes van Veen, Andrea C. Büchler, Yulia R. Saharman, Anis Karuniawati, Margreet C. Vos, Anne F. Voor in ’t holt, Juliëtte A. Severin   +7 more
doaj   +1 more source

Researching the Design of a Culturally Sensitive Library Science Course

, 2020
The overriding objective of this study was to conduct an exploratory participatory action research (Dudgeon, Scrine, Cox, & Walker, 2017; MacDonald, 2012; Reason & Bradbury, 2008) within a Third Space (Bhabha, 2009; Pitts & Brooks, 2017), to probe the viability of collaboratively developing the curriculum of a culturally sensitive library ...
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Best practices for supporting researchers’ mental health in emotionally demanding research across academic and non-academic contexts

International Journal of Qualitative Studies on Health & Well-Being
Purpose Researcher mental health in emotionally demanding research (EDR) has been recognized as important, but research to date has often been limited to academic research contexts, qualitative research, or single disciplines.
Mary L. Quinton, Karen L. Shepherd, Jennifer Cumming, Grace Tidmarsh, Maria R. Dauvermann, Sian L. Griffiths, Sally Reynard, Amanda Skeate, Anita Fernandes, Tasneem Choucair, James Downs, Karen Harrison Dening, Meghan H. McDonough, Lizzie Mitchell, Daniel J. A. Rhind, Charlie Tresadern   +15 more
doaj   +1 more source

Identifikasi Aksi Gen Epistasis pada Toleransi Kedelai terhadap Cekaman Aluminium [PDF]

, 2015
The efectiveness of selection depends on the gene action cotrolling the character. The presence of epistatic gene action will delay the genetic gain in self pollinated crops like soybean.
Sihaloho, A. N. (Arvita), Sopandie, D. (Didy), Trikoesoemaningtyas, T. (Trikoesoemaningtyas), Wirnas, D. (Desta)   +3 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source