Results 91 to 100 of about 14,735,798 (370)

Intimate and Personal Sphere in the System of Vital Values of the Anomalous Person – the Offender

open access: yesLaw and Safety, 2019
The study of the peculiarities of the structural and dynamic characteristics of the value and content sphere of the anomalous personality remains within the scope of actual psychological problems. The purpose of this study is to analyze the peculiarities
A. M. Bolshakova   +3 more
doaj   +1 more source

Culture and Learning [PDF]

open access: yes, 2010
Ensuring "the development of the child ... to the maximum extent possible" is part of every child’s rights under the UN Convention on the Rights of the Child.

core  

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Peculiarities of sensory motion reactions by students of KSAPC

open access: yesСлобожанський науково-спортивний вісник, 2018
Purpose: to establish the features of the manifestation of sensorimotor reactions by students of various specializations of KSAPC. Material & Methods: analysis of scientific and methodological information, generalization of best practical experience ...
Yura Tropin   +4 more
doaj   +1 more source

Patient Safety Culture Status and Its Predictors Among Healthcare Workers [PDF]

open access: yes, 2018
Good patient safety culture of healthcare professionals brings about fine consequences for patients. This study, therefore, aimed in evaluating the current status and predictors of safety culture among healthcare workers in Mekelle Zone hospitals, Tigray,
Aregay, A. (Alemseged)   +2 more
core  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Supporting a Culture of Evidence-Based Practice and Continuous Program Improvement: A Staged Approach to Implementing and Studying International Early Childhood Development Programs [PDF]

open access: yes
This concept paper proposes a four-stage approach to in-country/region ECD program development, selection, and inquiry designed to build the evidence base required to guide program and policy decisions. The foundation of the approach is a strengths-based
Christine Ross   +2 more
core  

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

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