Results 131 to 140 of about 14,322,637 (389)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

TISSUE CULTURE STUDIES ON BACTERIAL ALLERGY IN EXPERIMENTAL BRUCELLOSIS [PDF]

open access: bronze, 1958
Dorothy H. Heilman   +2 more
openalex   +1 more source

Libre culture: meditations on free culture [PDF]

open access: yes, 2008
Libre Culture is the essential expression of the free culture/copyleft movement. This anthology, brought together here for the first time, represents the early groundwork of Libre Society thought.
Berry, David M, Moss, Giles
core  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Stratégie de recherche du ministère de la Culture 2017-2020 (La) [PDF]

open access: yes
Ce rapport, présentant la stratégie de recherche 2017-2020 du ministère de la Culture, repose sur le travail accompli entre 2014 et 2016 par un comité de pilotage de la recherche Culture.
Ministère de la Culture
core  

Learning From the Historical Culture of American People for the Current Society [PDF]

open access: yes, 2019
We learned more about the contribution of cultural history towards the current society for the American people. In the most general sense, historical culture is a holistic meta-historical concept that opens the investigation of how people deal with the ...
Alley, F. (Fatihiya), Liu, S. (Siyung)
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Cultural Responsiveness, Racial Identity and Academic Success: A Review of Literature [PDF]

open access: yes, 2009
Commissioned by the Heinz Endowments, this paper reviews the literature on "culturally responsive pedagogy" and the arts. Academic success among African Americans is correlated with education that incorporates racial identity and socialization and a ...
George W. Noblit, Mary Stone Hanley
core   +1 more source

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