Results 121 to 130 of about 8,891,769 (355)
EludamosTraditionally, theories of play and games have drawn a clear distinction between two different forms of activity; play and labour. Over the last two decades, the concept of playbour has challenged this division, with empirical studies and observations ...
Tuomas Manninen
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Popüler Kültür ve Müzikte Anlamın Kaybı
Akademik İncelemeler Dergisi, 2015 Avrupa’da 17. yüzyıldan itibaren başlayan ekonomik, toplumsal, siyasal ve sosyal alanda yaşanan köklü değişimlerin ifadesi olan modernite, zamanla tüm dünyayı etkisi altına almıştır. Pek çok alanla birlikte özellikle kültür anlayışı ve sanata yansımaları
Mehmet Birekul
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
A Little Death Around the Eyes
Kulturella Perspektiv, 2009 This article discusses the relationship between pre-romantic Anglo-Saxon literature, iconology in late modern music industry, artistry performance and heroin abuse in Pete(r) Doherty's musical universe. Through the concept of 'autofiction' which include
Sarah Holst Kjær
doaj +1 more source
Culture dimensions in software development industry: The effects of mentoring [PDF]
, 2011 Software development is a human centric and sociotechnical activity and like all human activities is influenced by cultural factors. However, software engineering is being further affected because of the globalization in software development. As a result,
Casado-Lumbreras, Cristina +3 more
core +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Microbial population dynamics in rubber coagula from Hevea brasiliensis [PDF]
, 2013 Natural rubber produced from the tree Hevea brasiliensis is a material of first importance for the tyre industry and for many other sectors such as the vibration isolation and the general rubber good industries. To produce TSR10 or 20 block rubber, trees
Bonfils, Frédéric +8 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source