Results 101 to 110 of about 6,653,826 (260)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Culture and the Survival of UK Independent Games Software Firms [PDF]
This paper reports on qualitative research that investigates the culture of survival among entrepreneurial UK games software development firms within the interactive entertainment industry.
Denise Tsang
core
Culture, Cultural Industries and Creative Industries.
, 2006 La culture, passée et sédimentée en un patrimoine, créée dans les processus de créativité, apparaît comme facteur de production dans les industries culturelles mais aussi dans des industries, parfois très éloignées, comme le parfum, la mode, la restauration. Culture et industrie se trouvent alors en interrelation.
openaire +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A Framework for Industry Export Competitiveness: Evidence from the Alcoholic Beverages Industry
, 2008 Participation in international trade is a key indicator of an industry’s competitiveness. This study presents a framework for measuring the export competitiveness of an industry across countries that takes into account (a) industry specialization ...
Johnson, James P. +2 more
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Strategic Adaptation to Deregulation in the Indian Auto Components Industry [PDF]
, 2008 We explore the strategic adaptation by domestic firms subsequent to economic liberalization and industry deregulation in an emerging economy. We study the Indian auto components industry during a ten-year period (1992-2002), using the Prowess database ...
Tripathy, Arindam +3 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Innovation Challenges in the Lighting Industry From 1990 to 2006 [PDF]
, 2007 The lighting industry faces major competitive challenges with the introduction of new solid-state lighting technologies. Solid-state lighting’s greater energy efficiency, lifetime, and other features have led to widespread adoption in backlights ...
Sanderson, Susan +3 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source