Results 141 to 150 of about 675,164 (342)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ad Fontes: Desiderius Erasmus’ Call for a Return to the Sources of a Unified and Simple Christian Faith [PDF]
, 2017 Desiderius Erasmus’ humanism greatly shaped his view of Christianity. He developed a “philosophy of Christ” that led him to seek peaceful reforms from within the Church while attempting to maintain unity.
Kieffer, Amanda
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Hilltops and Marches: A Cultural and Semiotic Analysis of Pepsi and Coca-Cola Advertising Strategies [PDF]
, 2018 The Coca-Cola Company released an advertisement in 1971 that had powerful themes of unity in a time of significant discord around the world. Almost 50 years later, the Pepsi Company released an advertisement that aimed to accomplish similar values of ...
Herrmann, Samuel
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
A New Account of Personalization and Effective Communication [PDF]
To contribute to understanding of information economies of daily life, this paper explores over the past millennium given names of a large number of persons. Analysts have long both condemned and praised mass media as a source of common culture, national
Douglas A. Galbi
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
POSTMODERNISMUL – CADRU AL DIVERSITĂŢII EDUCAŢIONALE
Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2010 Postmodernity is the age of thinking, not so much of fragmentation, as of plurality, even the shift from unity to plurality is a form of our existence. Diversity is both an intrinsic attribute of nature and culture. As regards culture, without diversity,
USM ADMIN
doaj
Pengaruh Budaya Kerja Terhadap Komitmen Karyawan PT Indofood CBP Sukses Makmur Tbk Cabang Bandung Divisi Noodle [PDF]
, 2015 PT Indofood CBP Sukses Makmur Branch Bandung Noodle Division is a company that realizes the importance of work culture and commitment. It is proven by the work culture that the company have implemented in order to guarantee better quality work result ...
Hermayanti, A. (Anne) +1 more
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