Results 141 to 150 of about 39,746 (312)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2015 From the perspective of production practice, the national unity education emphasizes, in educational relations, teachers are in the dominant position with teacher-centered tendencies, and college students are in the object position, heavily politicized ...
JIANG, Han
core
Вестник Донского государственного технического университета, 2018 In this article attempt to interpret the phenomenon of cognitive world through axiological prism of universalies of culture is undertaken. Is explicized categorial sense of criterion of the rationality, being the common for all stages of development of ...
S.Y. NIKOLAEV
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Elusive unity: factionalism and the limits of identity politics in Yucatán, Mexico
, 2013 Includes bibliographical references.In Elusive Unity, Armstrong-Fumero examines early twentieth-century peasant politics and twenty-first-century indigenous politics in the rural Oriente region of Yucatan the rural inhabitants of this region have had ...
Armstrong-Fumero, Fernando, author +1 more
core
A cultural unity for the Common European Project
, 2015 This article analyses the impact of the process of European integration on the cultural unity of the European Union (EU). The most powerful outcome underpinning the international significance of the EU has been the establishment of a remarkable set of institutions, together with the political practices above and beyond the tradition framework of the ...
openaire +1 more source