Results 131 to 140 of about 675,164 (342)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Towards a cultural history of the Popular unity

open access: yes, 2023
Despite the abundant historiography on the Unidad Popular, it has been approached mainly from the perspective of political history and international relations. Relatively few works have approached the so-called “Chilean road to socialism” from the perspective of cultural history.
Compagnon, Olivier   +2 more
openaire   +1 more source

Konsumen Dan Film(Studi tentang Perlindungan Hukum dalam film-film Religi) [PDF]

open access: yes, 2018
National films are growing along with technological developments. Legal protection for national film consumer is governed by the laws and regulations that the national Film that is broadcasted should not be contradictory to Law Number 8 Year 1999 ...
, Dr. Kelik Wardiono, S.H., M.H.   +1 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

AXIOLOGICAL REFRACTION OF RATIONALITY AS RELEVANT ASPECT OF THE PROJECTION OF BECOMING OF THE MODERN POSTNONCLASSICAL SCIENTIFIC PARADIGM

open access: yesAdvanced Engineering Research, 2021
In this article attempt to interpret the phenomenon of cognitive world through axiological prism of universalies of culture is undertaken. Is explicized categorial sense of criterion of the rationality, being the common for all stages of development of ...
S.Y. NIKOLAEV
doaj  

God and the Global Economy: Religion and Attitudes Towards Trade and Immigration in the United States [PDF]

open access: yes, 2005
Using the results of a national identity survey, we test the impact of religious affiliation on trade and immigration-policy preferences of US residents while controlling for individual level of skill, political ideology and other important demographic ...
Daniels, Joseph P., von der Ruhr, Marc
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Vasily Sesemann’s Philosophy of Culture

open access: yesRUDN Journal of Philosophy
The research is devoted to the analysis of the works of Vasily Sesemann (1884-1963) on the philosophy of culture. The relevance of the study is determined by the lack of special works devoted to the explication of the thinker’s views on the phenomenon of
Julia V. Sokolova
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy