Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Hydroponics or Soilless Culture [PDF]
Historically, hydroponics is not a new field; plant physiologists have known and used it for some 100 years. Inevitably, some enthusiasts got carried away.Claims were made of enormous potential yields; skyscraper tops were said to be capable of producing
Chapman, H. D.
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Internet: Culture Diversity and Unification [PDF]
Culture specifics of the Internet usage is analysed. The analysis done is a preliminary work for the application of the socio-historical theory of human mental development.
Voiskounsky, Alexander E.
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Severe acute respiratory syndrome coronavirus 2 environmental contamination in hospital rooms is uncommon using viral culture techniques. [PDF]
Warren BG +11 more
europepmc +1 more source
DEVELOPMENT OF AUTOMATED VISION TECHNIQUES FOR IMMEDIATE ANALYSIS AND CONTROL OF BETALAIN-PRODUCING CELL CULTURES [PDF]
Mark A. Smith +3 more
openalex +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Aquaculture Asia, Vol. 11, No. 1, pp.1-36, January - March 2006 [PDF]
*Table of Contents* Research & farming techniques Nursery rearing of Puntius goniotus: A preliminary trial K.N. Mohnta, J.K. Jena & S.N. Mohanty Artemia enrichment and biomass production for larval finfish and shellfish culture A.S.
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Ex vivo development of the entire mouse fetal reproductive tract by using microdissection and membrane-based organ culture techniques. [PDF]
Jia S, Zhao F.
europepmc +1 more source
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Knowledge management driven leadership, culture and innovation success – an integrative model [PDF]
Purpose - This article examines the relation between knowledge management (KM) driven leadership, culture and innovation success of knowledge-intensive small and medium sized companies.
Schivinski, B, Zięba, M
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