Results 111 to 120 of about 448,635 (294)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Population‐based study evaluating and predicting the probability of death resulting from thyroid cancer among patients with papillary thyroid microcarcinoma

Cancer Medicine, 2019
Background Papillary thyroid microcarcinoma (PTMC) is an indolent carcinoma. The cumulative incidence of death from patients with PTMC and the nomogram built based on the competing risks model have not been described. Methods Patients diagnosed with PTMC
Kun Wang, Jing Xu, Shuyu Li, Shiyang Liu, Lin Zhang   +4 more
doaj   +1 more source

The Bernstein-Von Mises Theorem in Semiparametric Competing Risks Models [PDF]

Semiparametric Bayesian models are nowadays a popular tool in survival analysis. An important area of research concerns the investigation of frequentist properties of these models.
Nils L. Hjort, Pierpaolo De Blasi
core  

A joint model for the emission and absorption properties of damped Lyman alpha absorption systems

, 2008
The recently discovered population of ultra-faint extended line emitters can account for the majority of the incidence rate of Damped Lyman Alpha systems (DLAs) at z ~ 3 if the line emission is interpreted as Ly alpha.
Bouché, Brocklehurst, Bryan, Bunker, Carroll, Christensen, Cooke, Dijkstra, Eisenstein, Ellison, Fabian, Fynbo, Fynbo, Gardner, Gardner, Gardner, Haehnelt, Haehnelt, Hinshaw, Jedamzik, Johansson, Kennicutt, Kereš, Kulkarni, Kulkarni, Le Delliou, Luke A. Barnes, Maller, Maller, Martin G. Haehnelt, Nagamine, Nagamine, Pettini, Press, Prochaska, Prochaska, Prochaska, Péroux, Rauch, Razoumov, Sheth, Storrie-Lombardi, Storrie-Lombardi, Warren, Wild, Wolfe, Wolfe, Wolfe, Wolfe, Zwaan   +49 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Duration and Risk of Unemployment in Argentina [PDF]

, 2001
After a decade of structural reforms, unemployment rates have tripled in Argentina. This paper is concerned with the measurement of unemployment risk and its distribution.
Galiani, Sebastian, Hopenhayn, Hugo A.
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Semiparametric regression on cumulative incidence function with interval-censored competing risks data and missing event types. [PDF]

Biostatistics, 2022
Park J, Bakoyannis G, Zhang Y, Yiannoutsos CT.   +3 more
europepmc   +1 more source