Results 81 to 90 of about 192,913 (255)

Cumulative incidence function estimation using population-based biobank data

Biometrics
ABSTRACT Many countries have established population-based biobanks, which are being used increasingly in epidemiological and clinical research. These biobanks offer opportunities for large-scale studies addressing questions beyond the scope of traditional clinical trials or cohort studies. However, using biobank data poses new challenges.
Malka Gorfine, David M Zucker, Shoval Shoham   +2 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Crude incidence in two-phase designs in the presence of competing risks

BMC Medical Research Methodology, 2016
Background In many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies.
Paola Rebora, Laura Antolini, David V. Glidden, Maria Grazia Valsecchi   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Semiparametric regression on cumulative incidence function with interval-censored competing risks data and missing event types. [PDF]

Biostatistics, 2022
Park J, Bakoyannis G, Zhang Y, Yiannoutsos CT.   +3 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

A hierarchical competing risks survival model in the study of child mortality in Bangladesh

Scientific Reports
Under-five child mortality remains a significant public health issue in Bangladesh and other developing countries. Identifying key risk factors within a hierarchical data structure is crucial for improving health system performance.
Nazmul Haque, Mohammad Anamul Haque, Sheikh Sifat Sadikeen, Md. Jamal Uddin   +3 more
doaj   +1 more source

Association between kidney function trajectories and cardiovascular disease incidence among rural Uyghur residents in Xinjiang: a prospective cohort study

Zhongguo gonggong weisheng
ObjectiveTo understand the relationship between kidney function trajectories and cardiovascular disease (CVD) incidence among adult rural Uyghurs in Xinjiang Uyghur Autonomous Region (Xinjiang), and to provide a reference for early detection and ...
Xuehong XU, Jia HE, Rulin MA, Heng GUO, Xianghui ZHANG, Xin QIAN, KEERMAN Mulatibieke, Xinping WANG, MAIMAITIJIANG Remina, Shuxia GUO   +9 more
doaj   +1 more source