Results 131 to 140 of about 8,217,055 (263)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Age-specific anti-Mullerian hormone (AMH) levels poorly affects cumulative live birth rate after intra-uterine insemination

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2019
Objective: To evaluate the impact of age-specific anti-Mullerian (AMH) levels on the cumulative live birth rate after 4 intra uterine inseminations (IUI).
Jessika Moreau, Nicolas Gatimel, Cynthia Simon, Clémentine Cohade, Florence Lesourd, Jean Parinaud, Roger Léandri   +6 more
doaj   +1 more source

PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS

Journal of Assisted Reproduction and Genetics, 2022
Alexander Kucherov, M. Fazzari, H. Lieman, G. Ball, K. Doody, S. Jindal   +5 more
semanticscholar   +1 more source

Comparison of Cumulative Live Birth Rates Between Fresh and Vitrified Donor Oocytes

Cureus
Background Oocyte donation is a well-established treatment for age-related infertility, diminished ovarian reserve, and other reproductive challenges. The introduction of vitrification has expanded its feasibility by enabling oocyte cryobanking, reducing logistical constraints, and improving accessibility.
Kostoglou, Kyparissia, Michos, Georgios, Najdecki, Robert, Tsakiridis, Ioannis, Tatiana, Chartomatsidou, Chouliara, Foteini, Dagklis, Themistoklis I, Mamopoulos, Apostolos M, Papanikolaou, Evangelos   +8 more
openaire   +2 more sources

Cumulative live birth rate followingin vitrofertilization: Study of 5310 cycles

Gynecological Endocrinology, 2006
Most previous studies that calculated cumulative delivery rates following in vitro fertilization (IVF) treatments were limited in the number of cycles and the implementation of intracytoplasmic sperm injection (ICSI). Therefore, we assessed the yield of high-order consecutive IVF treatments (up to 14 consecutive cycles) with and without ICSI. Data from
Shai E, Elizur, Liat, Lerner-Geva, Jacob, Levron, Adrian, Shulman, David, Bider, Jehoshua, Dor   +5 more
openaire   +2 more sources

The combined impact of maternal age and body mass index on cumulative live birth following in vitro fertilization.

, 2019
BACKGROUND: It is critical to evaluate the combined impact of age and body mass index on the cumulative likelihood of live birth following in vitro fertilization, as achieving a lower body mass index before infertility treatment often is recommended for ...
Farland, L. V., Ginsburg, E. S., Goldman, R. H., Zera, C. A., Thomas, A. M.   +4 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Cumulative live birth rate after oocyte in vitro maturation with a pre-maturation step in women with polycystic ovary syndrome or high antral follicle count

Journal of Assisted Reproduction and Genetics, 2023
H. Pham, A. Le, A. M. Nguyen, U. Ha, Tri C. Nguyen, T. Pham, H. Le, T. K. Le, B. Huynh, T. Ho, L. Vuong   +10 more
semanticscholar   +1 more source