Results 191 to 200 of about 617,754 (317)

A quantile cure model with partially functional covariate effects. [PDF]

Stat Methods Med Res
Chen CM, Peng Y.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Remission with residuals, but no cure. [PDF]

Blood Adv
Al-Sawaf O.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

To cure or not to cure, that is not the question [PDF]

Journal of the Royal Society of Medicine, 2000
openaire   +1 more source

Clinical Outcomes of Metronidazole Monotherapy Versus Metronidazole Plus <i>Clostridium butyricum</i> MIYAIRI 588 Combination Therapy in Non-Severe <i>Clostridioides difficile</i> Infection: A Retrospective Cohort Study. [PDF]

BioTech (Basel)
Yamada Y, Nemoto M, Miyazaki M, Hirata H, Hosogoe K, Nakashima A, Kushima H, Ishii H, Imakyure O.   +8 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A license to cure [PDF]

Journal of the Royal Society of Medicine, 2018
Jing-Jing, Li, Chang-Qing, Gao
openaire   +2 more sources

Dissemination of EFFORT trial results in Indonesia: a stakeholder meeting report on tafenoquine and primaquine for radical cure of Plasmodium vivax. [PDF]

Malar J
Pasaribu AP, Jimanto V, Ainur F, Saragih NR, Hadi H, Siagian DSP, Sinaga BJ, Satyagraha AW, Laihad FJ, Diptyanusa A, Ubra RR, Tekege O, Darmayanti L, Herdiana H, Adella J, Mannion K, Curry E, Poespoprodjo JR, Kenangalem E, Burdam FH, Sutanto I, Nelwan EJ, Ganadhi GJ, Shrestha B, Mnjala H, Hawley WA, Prameswari HD, Theodora M, Silalahi FSM, Susanto H, Immanuella F, Puspadewi RT, Fajariyani SB, Samad I, Supriyanto D, Muhafilah N, Isa R, Price RN, Thriemer K.   +38 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source