Results 31 to 40 of about 1,474,552 (311)

Assessment of Barriers to Referral and Appointment Wait Times for the Evaluation of Spinal Muscular Atrophy (SMA): Findings from a Web-Based Physician Survey

Neurology and Therapy
Background Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. Clinical trial data suggest early diagnosis and treatment are critical.
Mary A. Curry, Rosángel E. Cruz, Lisa T. Belter, Mary K. Schroth, Jill Jarecki   +4 more
doaj   +1 more source

Fatal Relapse of Myelodysplastic Syndrome in a Patient with HIV/Hepatitis C Coinfection Treated with Simeprevir/Sofosbuvir

Journal of the International Association of Providers of AIDS Care, 2017
Registrational studies and observational cohorts clearly suggest sustained virologic response (SVR) rates in HIV-/hepatitis C–coinfected patients are similar to monoinfected patients when utilizing interferon-free regimens, and this can be accomplished ...
Efemena Michael Diejomaoh MD, Joseph Clayton Gathe MD, FACP, FIDSA, Carl Craig Mayberry PA-C, John Benjamin Clemmons MD, Bernie Miguel MD, Alan Glombicki MD, Benjamin Daquioag MD   +6 more
doaj   +1 more source

Chemotherapy Curability in Leukemia, Lymphoma, Germ Cell Tumors and Gestational Malignancies: A Reflection of the Unique Physiology of Their Cells of Origin

Frontiers in Genetics, 2020
Cytotoxic DNA damaging chemotherapy brings clinical benefits in the treatment of many metastatic malignancies. However routine curative treatment remains restricted to a small number of malignancies including acute leukemia, high grade lymphoma, germ ...
Philip Savage
doaj   +1 more source

Controversies in the Design of Strategies for the Cure of HIV Infection

Pathogens, 2023
The cure for chronic human immunodeficiency virus (HIV) infections has been a goal pursued since the antiretroviral therapy that improved the clinical conditions of patients became available.
Alejandro de Gea-Grela, Santiago Moreno
doaj   +1 more source

A Lorentzian cure for Euclidean troubles [PDF]

, 2002
There is strong evidence coming from Lorentzian dynamical triangulations that the unboundedness of the gravitational action is no obstacle to the construction of a well-defined non-perturbative path integral.
A. Dasgupta, Ambjørn, Ambjørn, Ambjørn, Ambjørn, Ambjørn, Dasgupta, Dehne, Distler, J. Ambj∅rn, J. Jurkiewicz, Loll, R. Loll   +12 more
core   +4 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

A qualitative, mixed-method approach to reaching consensus on function, fatigue, and fatigability outcomes in teens and adults living with spinal muscular atrophy

Orphanet Journal of Rare Diseases
Background Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in the survival motor neuron gene, SMN1. Loss of SMN1 function results in deficiency of the SMN protein leading to motor neuron death, muscle wasting, and progressive
Jacqueline Glascock, Lisa T. Belter, Meghan Moore Burk, Jessica J. Tingey, Mary A. Curry   +4 more
doaj   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Polymerization Efficiency of Glass-Ionomer and Resin Adhesives under Molar Bands [PDF]

, 2008
Objective: To determine the degree of cure of a light-cured resin-modified glass ionomer (RMGI) under molar bands compared with a light-cured resin and a dual-cured resin. Materials and Methods: The 3 cements used were Fuji Ortho LC, Eagle Spectrum resin,
Bradley, T. Gerard, Eliades, George, Eliades, Theodore, Rejman, Daniel John   +3 more
core   +1 more source