Results 131 to 140 of about 209,185 (318)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

What are Future Curing Lights Technology Trends?

open access: yes, 2010
Over the recent years, dental curing lights as well as light-cured materials have been undergoing rapid development, which makes choosing a curing light guaranteeing the optimal polymerization degree difficult.
D. Houšová   +3 more
core  

Analyzing the Accuracy of Estimates of Dental Curing Light Degradation from Cell Phone Images

open access: yes, 2020
Modern dentistry uses light-curing resin-based composites as restorative/flling materials. The LCU (dental light curing unit) is a device emitting blue light or a combination of blue and ultraviolet light to be placed directly over the tooth to harden
Chang, Yan
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Study on the Rheological Properties of BGAP Adhesive and Its Propellant

open access: yesMolecules
In order to study the curing process of branched polyazide glycidyl ether (BGAP) binder and its propellant slurry at 50 to 70 °C, the rheological properties of BGAP binder and its propellant slurry were studied by chemical rheology. The results show that
Yubao Shao   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Single component self-curable aqueous-based PU system with new aziridinyl curing agent

open access: yes, 2004
The self-emulsified aqueous-based polyurethane (PU) consists of carboxyl group, which is an ionic center not only stabilizing the aqueous polymer dispersion but also serving as the curing site toward aziridinyl curing agent.
Lai, Jian-zei; Chang, Yu-Ching; Yeh, Jen-taut; Chen, Kan-nan   +4 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Additive manufacturing of silicone for biomedical applications

open access: yesBiomedical Engineering Advances
The manufacturing of silicone-based elastomers has been the center of research for several decades and the renaissance of the manufacturing industry via additive manufacturing (AM) seems to verve the hype of the widespread industrial applications of ...
Deon Johan de Beer   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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