Results 131 to 140 of about 456,156 (304)

Currency Crises and Macroeconomic Performance [PDF]

open access: yes
This paper presents some theory and evidence on the implications of sudden currency depreciations for output and inflation. It identifies some of the characteristics shared by countries which have suffered falling output in the aftermath of a currency ...
Luke Gower, Alan Krause
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Twin Crises in Turkey: A Comparison of Currency Crisis Models [PDF]

open access: yes
This paper analyzes the twin crises in Turkey experienced in 2000 and 2001. After a detailed survey of currency crisis models, together with a brief descriptive overview of the crises in Turkey, the similarities among the twin crises in Turkey and the ...
Hakan Yilmazkuday
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

PROBABILITAS VARIABEL FUNDAMENTAL EKONOMI INDONESIA DAN TERHADAP TERJADINYA KRISIS FINANSIAL DI INDONESIA

open access: yesJurnal Ekonomi dan Bisnis Airlangga, 2012
The objective of this paper is to implement financial crisis model as part of an early warning system framework for Indonesia. This paper distinguish three types of financial crises, currency crises, banking crises and debt crises and extract four ...
Rossanto Dwi Handoyo
doaj  

The Role of Foreign Currency Debt in Financial Crises: 1880-1913 vs. 1972-1997 [PDF]

open access: yes
What is the role of foreign currency debt in precipitating financial crises? In this paper we compare the 1880 to 1913 period to recent experience. We examine debt crises, currency crises, banking crises and the interrelation between these varieties of ...
Michael D. Bordo   +1 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Explaining Financial Crises in Emerging Markets: A logit model on the Turkish data (1984-2001)

open access: yesLahore Journal of Economics
This article aims at explaining the financial crises Turkey experienced in the last decade through a random effects logit model which incorporates 26 macroeconomic, political, and financial sector variables.
Mete Feridun
doaj  

How bad are twins? output costs of currency and banking crises [PDF]

open access: yes
We investigate the output effects of severe banking and currency crises in emerging markets, focusing on whether “twin crises” (simultaneous occurrence of currency and banking crises) exist as a unique phenomenon and whether they entail especially large ...
Ilan Noy, Michael Hutchison
core  

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