Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Currency Crisis: The Case Of Iceland
International Business & Economics Research Journal (IBER), 2010 The purpose of this research paper is to analyze the Krona (the Icelandic currency) from an investment perspective while determining what has influenced its recent value deterioration. The paper looks at many different variables that have influenced the currency since the 1980s.
openaire +3 more sources
Can Currency Demand Be Stable Under a Financial Crisis? The Case of Mexico [PDF]
The paper finds strong evidence that real currency demand in Mexico remained stable throughout and after the financial crisis in Mexico. Cointegration analysis using the Johansen-Juselius technique indicates a strong cointegration relationship between ...
Alfredo M. Leone, By May Khamis
core
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Extreme Value Theory and the Incidence of Currency Crises [PDF]
A common feature of numerous studies on early warning systems (EWS) of currency crisis is the use of an index of exchange market pressure, defined as a weighted average of the rate of depreciation, the monthly percentage changes in international reserves,
Ramkishen Rajan, +2 more
core
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Global Financial Crisis: Did Exchange Rate Politics Help Emerging Countries To Be More Resilient?
International Journal of Economics and Financial Issues, 2013 In this paper, we try to explain how exchange politics help emerging economies to escape global financial crisis. We conduct a comparative analysis between two periods: financial crises period of the 1990’s and global financial crisis of 2007-2008.
Feryel Ouerghi
doaj +4 more sources
Japanese policy and the East Asian currency crisis: abject defeat or quiet victory? [PDF]
, 2000 Christopher W. Hughes
openalex +1 more source
An Empirical and Theoretical Study on the Wider Use of Local Currencies in the Asia-Pacific Region after the Asian Financial and Currency Crisis : An analysis focused on Thailand [PDF]
The Asian financial and currency crisis triggered a significant change to the currency composition of private liabilities in Thailand. Namely, the Thai private sector switched the denominations from the US dollar to the yen and at a larger percentage to ...
Ichiro Inoue
core +1 more source
Currency Substitution, Seigniorage, and Currency Crises in Interdependent Economies [PDF]
, 2003 This paper applies a two-country framework that allows for currency substitution in an environment in which policymakers optimally vary interest rates in light of utility-based objectives, one country pegs the value of its currency to the other nation’s ...
Daniels, Joseph P., VanHoose, David D.
core +1 more source