Results 91 to 100 of about 10,463,863 (300)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

The Effect of Transformer Magnetizing Inductance on a Forward Converter with Current Mode Control

open access: yes, 2012
[[abstract]]The small-signal model for a forward converter with current-mode control is derived which includes the magnetizing inductance of the main power transformer.
Chen, S. Y. ; Huang, K. ; Chen, Jin-Jia
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Drive current of accumulation-mode p-channel SOI-based wrap-gated Fin-FETs

open access: yes, 2011
Comparisons are performed to study the drive current of accumulation-mode(AM) p-channel wrap-gated Fin-FETs. The drive current of the AM p-channel FET is15%-26% larger than that of the inversion-mode(IM) p-channel FET with the same wrap-gated fin channel,
Zhang, Yanbo   +12 more
core   +1 more source

Current-mode flash analog-to-digital converter [PDF]

open access: yes
This thesis describes the development of a flash analog-to-digital converter based on current-mode technique. The advantages of current -mode technique are higher speed, smaller chip area, and simple division of reference current based on current mirror.
Maleki, Mohammad
core   +4 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

On mode competition during VIVs of flexible SFT's flexible cylindrical body experiencing lineally sheared current

open access: yes, 2016
Most of the floating tunnel and supporting tendon or cable of submerged floating tunnel (SFT) are essentially cylindrical body. Multi-mode vortex- induced vibration (VIV) of these flexible bodies frequently happens in non-uniform flow due to structural ...
陈伟民   +6 more
core   +1 more source

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