Results 131 to 140 of about 6,601,510 (205)

NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons. [PDF]

Front Synaptic Neurosci
Márton B, Ecsedi L, Pocsai K, Douida A, Lamsa K, Hutóczki G, Klekner Á, Pál B.   +7 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Highly sensitive X-ray detectors with polymer-perovskite-embedded flexible teflon membranes.

Mater Horiz
Sarisozen S, Lehnen AC, Hu F, Ofkeli G, von Reppert A, Rössle M, Ozen S, Kaya S, Holte L, Maslyanchuk O, Groszewicz PB, Hartlieb M, Neher D, Lang F.   +13 more
europepmc   +1 more source

TTX-S/TTX-R Na⁺ Currents Coordinately Fine-Tune Depolarization/Firing Capability Revealed by Voltage Derivatives/Displacement Current Phase Plots With Dynamic Current-Clamp Simulation in Rat Visceral Sensory Neurons. [PDF]

Acta Physiol (Oxf)
Jing-Ran Z, Hui-Xiao F, Xing-Yu L, Hong-Fei Z, Tian-Min D, Bai-Yan L, Di W.   +6 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Prevalence and correlates of current smoking among deaf, deafblind, and hard of hearing individuals. [PDF]

Am J Prev Med
Siddiqi S, Searls D, Kushalnagar P, Bergeron E, Caballero R, Alvarez G, Hayes E, Kamen C, Cupertino AP, Cartujano-Barrera F.   +9 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Alcohol Consumption During Pregnancy Among Women Aged 18-49 Years - United States, 2021-2024. [PDF]

MMWR Morb Mortal Wkly Rep
Thomas SA, Gosdin LK, Terplan M, Kim SY, Deputy NP.   +4 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Predictors of Tobacco Use Behaviors Among Syrian Americans. [PDF]

Tob Use Insights
Nakoud I, Arputhasamy C, Crespi CM, Mahho JF, Withers M, Cowgill BO.   +5 more
europepmc   +1 more source