Results 181 to 190 of about 662,882 (291)

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Global Evidence of the Unimodal Response of Ecosystem Respiration to Soil Moisture. [PDF]

Adv Sci (Weinh)
Peng J, Xie S, Tang J, Liao J, Chen C, Sun C, Wang Y, Zhou Q, Yu G, Niu S.   +9 more
europepmc   +1 more source

Does the United States have a current account deficit disorder? [PDF]

Presentation to the Business and Community Leaders Luncheon, The Lannom Center, Dyersburg, Tenn.
William Poole
core  

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Sexual Functioning in Individuals With Attention-Deficit Hyperactivity Disorder: A Narrative Review. [PDF]

Cureus
Puszcz A, Platnikow M, Antos Z, Czech M, Kipka A.   +4 more
europepmc   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Predictors of Outcome Clusters in Patients With Unruptured Intracranial Aneurysms Treated With Microsurgery: An Unsupervised Machine Learning Analysis. [PDF]

Neurosurg Pract
Koester SW, Ciobanu-Caraus O, Naik A, Rhodenhiser EG, Scherschinski L, Eberle AT, Hartke JN, Nico E, Hackett AM, Srinivasan VM, Winkler EA, Catapano JS, Lawton MT.   +12 more
europepmc   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Efficacy and safety of atomoxetine in the treatment of ADHD in children and adolescents: a systematic review. [PDF]

Front Child Adolesc Psychiatry
Barbosa Bastos De Souza Neto EA, Oliveira HF, Santos Ramos W, Martin Dantas EH, Alves Pereira BH, de Souza Mariano Bastos R.   +5 more
europepmc   +1 more source