Results 191 to 200 of about 1,529,833 (263)

KaSARi: a national framework for standardized, automated, and predictive radiotherapy in Finland. [PDF]

Acta Oncol
Seppälä J, Tengström M, Korkalainen H, Virén T, Honkanen JT, Nikkinen J, Lehtiö K, Ålgars A, Keyriläinen J, Suilamo S, Nurmi H, Skyttä T, Boman E, Vatanen T, Sailas L, Arkko UM, Vuolukka K, Koivumäki T, Metsäharju T, Voivalin T, Heikkilä J.   +20 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Expression Profile of the <i>SCNN1G</i> Gene and Its Association of Polymorphisms With Eggshell Quality Traits in the Potchefstroom Koekoek Chicken Breed. [PDF]

Vet Med Int
Molabe KM, Tyasi TL, Mbazima V.
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Microbiota-gut-brain axis and treatment resistance in epilepsy: a multicentre prospective study protocol (CARE). [PDF]

BMJ Open
Borghi E, Tassi L, d'Orsi G, Uzzau S, Pivari F, Ricci E, Longoni G, Mingarelli A, Previtali R, Berardi R, De Diego L, Vigano' I, Olivotto S, Compierchio E, Veggiotti P, Canevini MP, Vignoli A.   +16 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Legal Basis and Regulatory Requirements for Utilizing Real-World Evidence in Medical Product Regulatory Decision-Making. [PDF]

Pharmacoepidemiol Drug Saf
Park S, Han E.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Video gaming, nutrition and metabolic health: friend, foe, or both? [PDF]

Nutr Metab (Lond)
Siervo M, Egan SJ, Wells JCK.
europepmc   +1 more source