Results 211 to 220 of about 1,529,833 (263)

<b>E</b>quitable <b>P</b>alliative care <b>I</b>n the <b>C</b>ommunity through <b>P</b>rimary <b>C</b>are (EPIC-PC) study protocol: a realist study to propose a new integrated neighbourhood team approach to palliative care. [PDF]

BMJ Open
Mitchell S, Birtwistle J, Javeed A, Beng J, Hulbert L, Paley CA, Couchman E, Cocco P, Allsop M, Aunger J, Webb E, Dawkins B, Murtagh FEM, Evans C, Ziegler L.   +14 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Mapping the Clinical Evidence on Remimazolam in Anaesthesia: A Protocol for a Scoping Review. [PDF]

Acta Anaesthesiol Scand
Nilsson EHVS, Abood I, Møller AM.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Advancing healthcare worker safety in an academic hospital setting: a mixed methods quality improvement initiative protocol. [PDF]

Front Health Serv
Sharma S, de Bie L, Fletcher C, Rodrigues M, Depestel B, Cowell B, Monzavi-Bacon S, Bowman C, Prieur AJ, Puma C, Adu-Basowah K, Weeks C, Rabbat C, Thabane L, Heenan M.   +14 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The interventional value and research progress of vaginal microbiota transplantation in improving female sexual quality of life associated with dysbiosis of the reproductive microecosystem. [PDF]

Front Med (Lausanne)
Shi R, Ye X, Tan Y, Zhou R, Zheng X, Wang L.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The impact of high-grade complications on quality of life and psychosocial distress in the early period after radical cystectomy. [PDF]

BJUI Compass
Müller G, Bahlburg H, Götte M, Butea-Bocu MC, Roghmann F, Noldus J.   +5 more
europepmc   +1 more source