Results 111 to 120 of about 10,981,473 (283)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Topology and Control Method for Operational Testing of ±800 kV/8 GW Flexible DC Transmission Modular Multilevel Converter Valve

IEEE Access
Due to the relatively low operational reliability of the MMC valve, it is necessary to establish corresponding test methods to examine the tolerance of the valve to electrical and thermal stresses under engineering requirements through operational tests,
Qing Liu, Peng Chen, Sixu Liu, Chenggang Wang, Jianqiang Liu   +4 more
doaj   +1 more source

Derivation of Motor Mean Phase Currents in PMSM Drives Operating with Low Switching-to-Fundamental Frequency Ratio

Power Electronics and Drives, 2019
Pulse width modulation (PWM) of inverter output voltage causes the waveforms of motor phase currents to consist of distinctive ripples. In order to provide suitable feedback for the motor current controllers, the mean value must be extracted from the ...
Jarzebowicz Leszek
doaj   +1 more source

Surge current and electron swarm tunnel tests of thermal blanket and ground strap materials [PDF]

, 1977
The results are described of a series of current conduction tests with a thermal control blanket to which grounding straps have been attached. The material and the ground strap attachment procedure are described. The current conduction tests consisted of
Hoffmaster, D. K., Inouye, G. T., Sellen, J. M., Jr.   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Charting the Course for Integrated Diarrhea Control in Malawi: A Way Forward for Policy Change [PDF]

, 2011
In order for Malawi to achieve Millennium Development Goal 4, to reduce child mortality by two-thirds before 2015, this report addresses the issue of diarrheal disease by examining the current policy environment in Malawi.

core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Current-controlled oscillator

Electronics Letters, 1974
A relaxation oscillator whose frequency is linearly related to an input control current is described. The circuit configuration is based on the emitter-coupled astable multivibrator. The linear frequency variation is obtained by incorporating a discriminator circuit and high-transconductance elements into the oscillator circuit.
R. Sharma, T.R. Viswanathan
openaire   +1 more source