Results 121 to 130 of about 3,959,172 (249)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Improvement of Model Predictive Current Control Sensing Strategy for a Developed Small Flux-Switching Permanent Magnet Motor. [PDF]

Sensors (Basel), 2020
Pan CT, Wang SY, Chang CC, Yen CK, Wu JY, Ju SP, Lee RC.   +6 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Orbital exchange-mediated current control of magnetism. [PDF]

Nat Commun
Lee GH, Kim KW, Lee KJ.
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Breeding Wheat for Durable Leaf Rust Resistance in Southern Africa: Variability, Distribution, Current Control Strategies, Challenges and Future Prospects. [PDF]

Front Plant Sci, 2020
Figlan S, Ntushelo K, Mwadzingeni L, Terefe T, Tsilo TJ, Shimelis H.   +5 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Improved finite control set model predictive current control design for variable-speed wind-energy conversion system connected to the grid via an LCL filter. [PDF]

Sci Rep
Hamid HBA, Hassan JNA, Ali GH, Ma T, Ko C, Khan H, Mohammed OAA, Shahid A.   +7 more
europepmc   +1 more source

Design of a Measuring System for Electricity Quality Monitoring within the SMART Street Lighting Test Polygon: Pilot Study on Adaptive Current Control Strategy for Three-Phase Shunt Active Power Filters. [PDF]

Sensors (Basel), 2020
Martinek R, Bilik P, Baros J, Brablik J, Kahankova R, Jaros R, Danys L, Rzidky J, Wen H.   +8 more
europepmc   +1 more source