Depression: Current treatments with low-cost strategies [PDF]
British Journal of Mental Health Nursing, 2014 Depression has profound social, economic and personal consequences for the affected individual, and it shows no signs of abating in the general population. There are several treatment modalities available for this debilitating illness, however, effective as they are, these treatments have pitfalls. Antidepressants are the most common form of treatment
Phillips, Y., Mutsatsa, S.
openaire +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Current Cost Computing System Regarding Continuous Hospitalization Diagnosis in Romania [PDF]
Revista de Management Comparat International, 2013 Health care reform has produced changes in the health system infrastructure and personnel structure involved in providing health services in both the public and private sectors.
Gabriela Loredana DINULESCU
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Cost of Living/Cost of Smoking:A Demonstration Study of Cooperative Action Learning to Understand and Address Smoking in Deprived Communities Within the Cost-of-Living Crisis [PDF]
Smoking is responsible for over 8 million deaths globally per annum. While socially disadvantaged communities are disproportionately affected, few interventions effectively reach these groups.
Innocent, Wendy +12 more
core +1 more source
Cost‐effectiveness of aducanumab to prevent Alzheimer's disease progression at current list price
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction An estimated 6 million Americans have Alzheimer's disease (AD). Aducanumab was recently approved by the Food and Drug Administration despite the lack of clinical effectiveness data.
Pranay Sinha, Joshua A. Barocas
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Cost accounting in Spanish and Catalan universities: Its current status of implementation
Intangible Capital, 2017 Purpose: The main purpose of this paper is to analyse the development, implementation and use of different cost systems at universities. Design/methodology/approach: First, the need for a system of costs has been justified.
Ramon Saladrigues, Anna Tena
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source