Results 111 to 120 of about 1,829,206 (317)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Effect of current density on the morphology and electrochemical properties of nanotubular TiO2 for implant applications

Materials Research Express
This study focuses on investigating the influence of current density (i) (A/dm ^2 ) at values of 0.5 A dm ^−2 , 1.0 A dm ^−2 1.5 A dm ^−2 , and 2.0 A/dm ^2 on the surface structure of nanotubular titanium dioxide (TiO _2 ) in an ethylene glycol solvent ...
Van Toan Le, Quoc Tuan Ta, Vuong-Hung Pham   +2 more
doaj   +1 more source

Removing High-Velocity Oxyfuel Coatings Through Electrolytic Dissolution

Journal of Manufacturing and Materials Processing
High-velocity oxyfuel (HVOF) coatings are used to protect components from corrosion and wear at higher temperatures and from wearing out after a certain period of time. Hence, to enhance the life of components, further recoating is required, but removing
Zdeněk Pitrmuc, Vivek Rana, Michal Slaný, Jiří Kyncl, Sunil Pathak, Libor Beránek   +5 more
doaj   +1 more source

Effect of ion current density on the properties of vacuum arc-deposited TiN coatings

, 2013
The influence of ion current density on the thickness\ud of coatings deposited in a vacuum arc setup has been investigated to optimize the coating porosity. A planar probe was used to measure the ion current density distribution across plasma flux.
Ostrikov, Kostya, Fang, Jinghua, Rider, Amanda E., Fang, J, Kumar, S, Rider, AE, Baranov, Oleg O., Baranov, OO, Ostrikov, K, Kumar, Shailesh   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Impact of Electrolytic Cell Parameters on the Boiling Rate of the Electrolyte During Electrolytic Plasma Processing

Computation
This study investigates the influence of electrolytic cell parameters on the electrolyte boiling rate during electrolytic plasma processing, a critical stage for plasma formation and subsequent surface modification.
Rinat Kurmangaliyev, Yeldos Mukhametov, Bauyrzhan Rakhadilov, Rinat Kussainov, Nurlat Kadyrbolat   +4 more
doaj   +1 more source

ELECTRIC FACTORS INFLUENCING THE COMPLEX EROSION PROCESSING BY INTRODUCING THE ELECTROLYTE THROUGH THE TRANSFER OBJECT [PDF]

Fiabilitate şi Durabilitate, 2014
The electric and electrochemical complex erosion processing is influenced by a great number of factors acting in tight interdependence and mutually influencing one another for achieving the stability of the processing process and achieving the final ...
Alin Nioata
doaj  

Effect of Applied Current Density of Plasma Electrolytic Oxidation Process on Corrosion Resistance of AZ31 Magnesium Alloy

, 2019
Impact of applied current density during the plasma electrolytic oxidation (PEO) process on corrosion resistance of AZ31 magnesium alloy was studied. The PEO coatings were prepared using four different current densities with values of 0.025 A/cm2, 0.05 A/
Branislav Hadzima, Matej Brezina, Martina Jackova, Daniel Kajanek   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

TESTING THE ELECTRIC EQUIPMENTS SUBJECT TO VIBRATIONS AND ANALYSIS OF THE TEMPERATURE UPON THE ELECTRIC RELAY

Nonconventional Technologies Review, 2015
The object of the paper presented hereby is that of achieving a study concerning the effects of heating upon the electric equipments, respectively the electrical relays to vibrations.
Claudia Olimpia Stasac, Dorel Anton Hoble   +1 more
doaj