Results 31 to 40 of about 4,987,306 (253)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Minimum-error discrimination between three mirror-symmetric states [PDF]
, 2002 We present the optimal measurement strategy for distinguishing between three quantum states exhibiting a mirror symmetry. The three states live in a two-dimensional Hilbert space, and are thus overcomplete.
B. Huttner +18 more
core +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
, 1965 Time and frequency domain convergence properties of causal and Current Iteration Tracking Error (CITE) discrete time Iterative Learning Control (ILC) algorithms are discussed.
Gunnarsson, Svante, Norrlöf, Mikael
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
The large-scale bias of the hard X-ray background [PDF]
, 2004 Recent deep X-ray surveys combined with spectroscopic identification of the sources have allowed the determination of the rest-frame 2-8 keV luminosity as a function of redshift. In addition, an analysis of the HEAO1 A2 2-10 keV full-sky map of the X-ray
Comastri A. +4 more
core +4 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
An integral formulation for wave propagation on weakly non-uniform potential flows
, 2016 An integral formulation for acoustic radiation in moving flows is presented. It is based on a potential formulation for acoustic radiation on weakly non-uniform subsonic mean flows.
Astley, R. Jeremy +4 more
core +3 more sources
Direct predictive current-error vector control for a direct matrix converter [PDF]
, 2018 This paper proposes a novel control strategy for matrix converters which is coined “Direct Predictive Current-error Vector Control”. The proposed control method retains the advantageous features of both a modulation scheme and of a predictive based ...
De Lillo, Liliana +3 more
core +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source