Results 51 to 60 of about 13,607,564 (266)

Pediatric Sepsis: a Summary of Current Definitions and Management Recommendations

Current Pediatrics Reports, 2023
Purpose of Review Pediatric sepsis remains an important cause of morbidity and mortality in children. This review will summarize the main aspects of the definition, the current evidence base for interventions discuss some controversial themes and point ...
Mariana Miranda, S. Nadel
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities

Biomedicines, 2022
Amniotic fluid (AF) provides critical biological and physical support for the developing fetus. While AF is an excellent source of progenitor cells with regenerative properties, recent investigations indicate that cell-free AF (cfAF), which consists of ...
Charles M. Bowen, Frederick S. Ditmars, Ashim Gupta, Jo-Anna Reems, William Samuel Fagg   +4 more
doaj   +1 more source

Current sepsis therapeutics

EBioMedicine, 2022
Summary Management of the patient with sepsis comprises three key branches: control of the underlying infection, haemodynamic stabilization, and modulation of the host response. Each aspect should be considered in all patients and, when relevant, managed
J. Vincent
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI.

New England Journal of Medicine, 2019
BACKGROUND The causative agents for the current national outbreak of electronic-cigarette, or vaping, product use-associated lung injury (EVALI) have not been established.
B. Blount, M. Karwowski, P. Shields, Maria Morel-Espinosa, L. Valentín-Blasini, Michael S Gardner, Martha Braselton, Christina Brosius, Kevin T Caron, D. Chambers, Joseph Corstvet, Elizabeth A. Cowan, V. D. De Jesús, Paul Espinosa, Carolina Fernandez, Cory Holder, Z. Kuklenyik, Jennifer D Kusovschi, Cody A. Newman, Gregory B. Reis, J. Rees, C. Reese, Lalith K. Silva, Tiffany H Seyler, Min-Ae Song, C. Sosnoff, C. Spitzer, D. Tevis, Lanqing Wang, C. Watson, M. Wewers, B. Xia, D. Heitkemper, Isaac Ghinai, J. Layden, P. Briss, Brian A. King, L. Delaney, Christopher M. Jones, G. Baldwin, Anita Patel, D. Meaney-Delman, D. Rose, Vikram Krishnasamy, J. Barr, Jerry Thomas, J. Pirkle   +46 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fluid Management for Critically Ill Patients: A Review of the Current State of Fluid Therapy in the Intensive Care Unit

Kidney Diseases, 2016
Background: Intravenous fluids (IVF) are frequently utilized to restore intravascular volume in patients with distributive and hypovolemic shock. Although the benefits of the appropriate use of fluids in intensive care units (ICUs) and hospitals are well
E. Frazee, K. Kashani
semanticscholar   +1 more source