Results 121 to 130 of about 4,998,742 (298)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Hardware Measurement Platform for Quantum Current Sensors

Engineering Proceedings
A concept towards current measurement in low and medium voltage power distribution networks is presented. The concentric magnetic field around the current-carrying conductor should be measured using a nitrogen-vacancy quantum magnetic field sensor.
Frederik Hoffmann, Ann-Sophie Bülter, Ludwig Horsthemke, Dennis Stiegekötter, Jens Pogorzelski, Markus Gregor, Peter Glösekötter   +6 more
doaj   +1 more source

Study of Damage Prediction of Carbon Fiber Tows Using Eddy Current Measurement. [PDF]

Polymers (Basel), 2023
Roh JU, Kwon H, Lee S, Ha JC, Yang SB, Lee H, Kwon DJ.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Eddy Current Measurement for Planar Structures. [PDF]

Sensors (Basel), 2022
Xia Z, Huang R, Chen Z, Yu K, Zhang Z, Salas-Avila JR, Yin W.   +6 more
europepmc   +1 more source

Measurement of $\mathcal{R}(D^*)$ with Three-Prong $\tau$ Decays at LHCb

, 2017
The observable $\mathcal{R} ( D^{(*)} ) = \mathcal{B}\left( B^{0}\to D^{(*)-} \tau^{+} \nu_{\tau} \right) / \mathcal{B}\left( B^{0}\to D^{(*)-} \mu^{+} \nu_{\mu} \right)$ is a probe for Lepton Universality violation, so it is sensitive to New Physics ...
Betti, Federico
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Study of the B-Dot Sensor for Aircraft Surface Current Measurement. [PDF]

Sensors (Basel), 2022
Tong C, Duan Z, Huang Y, Qiu S, Si X, Li Z, Yuan Z.   +6 more
europepmc   +1 more source

Current Issues in Antioxidant Measurement

Journal of Agricultural and Food Chemistry, 2019
The rationale and scope of the main issues of antioxidant measurement are presented, with basic definitions and terms in antioxidant research (such as reactive species and related antioxidative defenses, oxidative stress, and antioxidant activity and capacity) in a historical background.
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source