Results 131 to 140 of about 1,832,940 (315)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2009 This paper presents an integrated portable measurement system for the study of high speed and high temperature unsteady plasma flows such as those found in the vicinity of high current switching arcs.
Sharkh, S.M. +3 more
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Lightning Current Measurement Form and Arrangement Scheme of Transmission Line Based on Point-Type Optical Current Transducer. [PDF]
Sensors (Basel), 2023 Ge J, Yin Y, Wang W.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Performance measurement : challenges for tomorrow
, 2011 This paper demonstrates that the context within which performance measurement is used is changing. The key questions posed are: Is performance measurement ready for the emerging context? What are the gaps in our knowledge?
Sai Nudurupati +9 more
core +1 more source
Analysis of and Reduction in Noise in Current Measurement of XCP under the Laboratory Condition. [PDF]
Sensors (Basel), 2022 Liu Y +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Current Transformer Error Correction
This paper presents the development of micro- processor based device with ability to decrease protection-type current transformer measurement error in the area of small currents.
Dolgicers, Aleksandrs +1 more
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