Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Modified Current-Mode VCSEL Driver for Short-Range LiDAR Sensor Applications in 180 nm CMOS
PhotonicsThis paper presents a modified current-mode vertical-cavity surface-emitting laser (VCSEL) driver as a transmitter for short-range light detection and ranging (LiDAR) sensors, where a stable bias generator is suggested with a regulated cascode current ...
Juntong Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Spin Current and Shot Noise in Single-Molecule Quantum Dots with a Phonon Mode
, 2005 In this paper we investigate the spin-current and its shot-noise spectrum in a single-molecule quantum dot coupled with a local phonon mode. We pay special attention on the effect of phonon on the quantum transport property.
D. C. Langreth +5 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Single-Input Four-Output Current Mode Filter Using Operational Floating Current Conveyor
Active and Passive Electronic Components, 2013 This paper presents operational floating current conveyor (OFCC) based single input four output current mode filter. It employs only three OFCCs and two grounded capacitors and resistors each.
Neeta Pandey, Deva Nand, Zubair Khan
doaj +1 more source
Discrete time domain modeling and design of current mode controlled flyback LED driver. [PDF]
Sci Rep, 2023 Kim MG.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Sample preparation of free sterols from vegetable oils by countercurrent chromatography in co-current mode. [PDF]
Anal Bioanal Chem, 2023 Rüttler F +5 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source