Results 51 to 60 of about 28,360 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Analytical modeling and calculation of core grounding current in converter transformer [PDF]
, 2023 Xiu Zhou +6 more
openalex +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Elektrotehnìka ta Elektroenergetika, 2016 Мета роботи. Визначення максимальних величин струмових та кутових похибок трансформаторів струму та характеру їх зміни в усталених та перехідних режимах енергосистеми, за яких можливий вихід величин похибок за межі діапазону нормованих значень, а також у
V. V. Nitsenko +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Materials Research, 2012 In this paper are presented theoretical analysis and experimental results concerning the performance of toroidal cores used in current transformers. For most problems concerning transformers design, analytical methods are useful, but numerical methods ...
Benedito Antonio Luciano +4 more
doaj
On-site partial discharge test technology of converter transformer
The Journal of Engineering, 2018 The rectifier transformer is the power transformer of the rectifier equipment. The characteristic of the rectifier device is the AC input, DC output by rectifying the original.
Wei Wang +6 more
doaj +1 more source
The two-stage current transformer [PDF]
Journal of the American Institute of Electrical Engineers, 1922 This paper presents a brief discussion of the current transformer as used with measuring and controlling apparatus with special reference to the degree of accuracy which can be attained in the ratio and phase angle. A new type of current transformer is then described, in which it is possible to secure much higher accuracy with a given amount of iron ...
H. B. Brooks, F. C. Holtz
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source