Results 61 to 70 of about 900,658 (264)

Comparison of Critical Thinking and Clinical Decision Making Skills Among the Last-Semester Nursing Students and Practicing Nurses in Sabzevar University of Medical Sciences [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2013
Introduction: Critical thinking and clinical decision making skills lead to care improvement and the application of nursing process. Previous studies have indicated that critical thinking and clinical decision making skills among nurses and students are ...
Maryam Karimi Noghondar, Fatemeh Rahnama Rahsepar, Mahdi Golafrooz, Mohaddeseh Mohsenpour   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Concepciones Sobre Curriculum, El Contenido Escolar y El Profesor En Los Procesos De ElaboraciónDe Textos Curriculares En Argentina Conceptions About Curriculum, School Content and The teachers in the process to produce texts Curriculum in Argentina

Education Policy Analysis Archives, 2004
Este trabajo plantea una reflexión acerca de los procesos de diseño curricular que han tenido lugar en la Argentina en las dos últimas décadas. Su propósito es identificar las principales tendencias en las concepciones de los actores/diseñadores del ...
Alejandra Amantea, Graciela Laura Cappeletti, Estela Beatriz Cols, Silvina Feeney   +3 more
doaj  

Self-confidence and anxiety in clinical decision-making among nursing students during high-fidelity simulation training: a longitudinal study

Advances in Simulation
Background Clinical decision-making is a core nursing competency that develops progressively through education and practice. However, nursing students frequently report reduced self-confidence and increased anxiety when required to make clinical ...
Geert Van de Weyer, Filip Haegdorens, Senne Vleminckx, Deborah Hilderson, Erik Franck   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developing neonatal point-of-care lung ultrasound training using Kern's six-step approach: the experience from a UK tertiary neonatal unit

Pediatrics and Neonatology
Objectives: Despite the increasing recognition of the importance of neonatal lung ultrasound (LU) in the management of the unwell neonate, LU is not included in the UK neonatal curriculum.
Swapnaja Dongre, Dario Gallo, Anna Milan
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source