Results 131 to 140 of about 1,083,966 (327)
Molecular Oncology, EarlyView.High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto +3 more
wiley +1 more source
On the geometry and topology of manifolds of positive bi-Ricci curvature [PDF]
arXiv, 1997 We introduce some new curvature quantities such as conformal Ricci curvature and bi-Ricci curvature and extend the classical Myers theorem under these new curvature conditions. Moreover, we are able to obtain the Myers type theorem for minimal submanifolds in ambient manifolds with positive bi-Ricci curvature.
arxiv
Molecular Oncology, EarlyView.Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores +14 more
wiley +1 more source
Period problems for mean curvature one surfaces in $H^3$ (with application to surfaces of low total curvature) [PDF]
Adv. Studies in Pure Math. 51 (2008), 335-387, Surveys on Geometry
and Integrable Systems, 2008 We review recent results on classifying complete constant mean curvature 1 (CMC 1) surfaces in hyperbolic 3-space with low total curvature. There are two natural notions of "total curvature" -- one is the total absolute curvature, which is the integral over the surface of the absolute value of the Gaussian curvature, and the other is the dual total ...
arxiv
Nature Communications, 2018 The ability of proteins to sense membrane curvature is essential to cellular function. All known sensing mechanisms rely on protein domains with specific structural features such as wedge-like amphipathic helices and crescent-shaped BAR domains. Yet many
Wade F. Zeno +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Study of the curvature of green pieces in stoneware ceramic tiles
Boletín de la Sociedad Española de Cerámica y Vidrio, 2000 Ceramic tiles undergo some deformations on the production line. After pressing, tiles are flat but, in subsequent stages of the production line, surfaces are wetted producing temperature and water gradients across their thickness.
de Pablos, A. +6 more
doaj
Curvature and transport inequalities for Markov chains in discrete spaces [PDF]
arXiv, 2015 We study various transport-information inequalities under three different notions of Ricci curvature in the discrete setting: the curvature-dimension condition of Bakry and \'Emery, the exponential curvature-dimension condition of Bauer \textit{et al.} and the coarse Ricci curvature of Ollivier.
arxiv
Molecular Oncology, EarlyView.The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits +7 more
wiley +1 more source