Results 51 to 60 of about 267,369 (299)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
CFD study of some factors affecting performance of HAWT with swept blades
International Journal of Sustainable Energy, 2017 Most modern high-power wind turbines are horizontal axis type with straight twisted blades. Upgrading power and performance of these turbines is considered a challenge.
M.G. Khalafallah, A.M. Ahmed, M.K. Emam
doaj +1 more source
Spin polarization through a molecular junction based on nuclear Berry curvature effects [PDF]
, 2022 Hung-Hsuan Teh +2 more
openalex +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Mechanism of Casing String Curvature Due to Displacement of Surface Strata
Energies, 2022 One of the main problems of well operation is the risk of uncontrolled leakage of hydrocarbons into the environment. This problem is especially relevant for the long-term operation of wells.
Maciej Dutkiewicz +3 more
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The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Mannheim curves and their partner curves in Minkowski 3-space E13
Demonstratio Mathematica, 2022 The modified orthogonal frame is an important tool to study analytic space curves whose curvatures have discrete zero points. In this article, by using the modified orthogonal frame, Mannheim curves and their partner curves are investigated in Minkowski ...
Elsharkawy Ayman, Elshenhab Ahmed M.
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
APPLICATIONS OF THE SPACE DIFFERENTAL GEOMETRY AT THE STUDY OF PRODUCTION FUNCTIONS
EIRP Proceedings, 2006 This paper is a new onset about production functions. Because all papers on this subject use the projections of production functions on a plan, the analysis becomes heavy and less general in conclusions, and for this reason we made a treatment from the ...
Catalin Angelo Ioan
doaj