Results 61 to 70 of about 998,625 (264)
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Clinical Remarks on the Treatment of Angular Curvature of the Spine [PDF]
, 1887 R. Davy
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Nonnegative Curvature on Piecewise Constant Curvature Spaces [PDF]
Transactions of the American Mathematical Society, 1992 We consider piecewise flat and piecewise spherical spaces. We prove that every piecewise flat cobordism which is a product near the boundary and has nonnegative curvature must be trivial in the metric sense. We also obtain several restrictions for piecewise p p -spherical manifolds with nonnegative curvature and diameter equal to
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Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
RACHILYSIS: A METHOD OF TREATING THE SEVERER FORMS OF LATERAL CURVATURE. [PDF]
, 1889 Richard Barwell
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Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 1989 A special motion of the dual unit sphere is studied and then with help of the Study map interpreted in the space of lines of three-dimensional Euclidean space. The motion is defined so that two points of the moving dual unit sphere are restricted to move on two circles. This gives a generalisation of a spherical slider-crank motion.
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source