Results 111 to 120 of about 464,650 (293)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

The Symmetry Group of Lamé's System and the Associated Guichard Nets for Conformally Flat Hypersurfaces

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2013
We consider conformally flat hypersurfaces in four dimensional space forms with their associated Guichard nets and Lamé's system of equations. We show that the symmetry group of the Lamé's system, satisfying Guichard condition, is given by translations ...
João Paulo dos Santos, Keti Tenenblat
doaj   +1 more source

Q-Curvature, Spectral Invariants, and Representation Theory [PDF]

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2007
We give an introductory account of functional determinants of elliptic operators on manifolds and Polyakov-type formulas for their infinitesimal and finite conformal variations. We relate this to extremal problems and to the Q-curvature on even-dimensional conformal manifolds.
openaire   +5 more sources

NON-COERCIVE RICCI FLOW INVARIANT CURVATURE CONES

open access: yes, 2015
This note is a study of nonnegativity conditions on curvature preserved by the Ricci flow. We focus on a specific class of curvature conditions which we call non-coercive: These are the conditions for which nonnegative curvature and vanishing scalar ...
Richard, Thomas, Seshadri, Harish
core  

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park   +5 more
wiley   +1 more source

On Cohomological Decomposability of Almost-Kähler Structures [PDF]

open access: yes, 2012
We study the J-invariant and J-anti-invariant cohomological subgroups of the de Rham cohomology of a compact manifold M endowed with an almost-K\"ahler structure (J, \omega, g).
Tomassini, Adriano   +2 more
core  

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto   +12 more
wiley   +1 more source

Curvature invariant on noncommutative polyballs

open access: yesAdvances in Mathematics, 2015
In this paper we develop a theory of curvature (resp. multiplicity) invariant for tensor products of full Fock spaces and also for tensor products of symmetric Fock spaces. This is an attempt to find a more general framework for these invariants and extend some of the results obtained by Arveson for the symmetric Fock space, by the author and Kribs for
openaire   +3 more sources

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy