Results 91 to 100 of about 201,081 (270)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
More on complexity of operators in quantum field theory
Journal of High Energy Physics, 2019 Recently it has been shown that the complexity of SU(n) operator is determined by the geodesic length in a bi-invariant Finsler geometry, which is constrained by some symmetries of quantum field theory.
Run-Qiu Yang +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Invariant Surfaces under Hyperbolic Translations in Hyperbolic Space
Journal of Applied Mathematics, 2014 We consider hyperbolic rotation (G0), hyperbolic translation (G1), and horocyclic rotation (G2) groups in H3, which is called Minkowski model of hyperbolic space.
Mahmut Mak, Baki Karlığa
doaj +1 more source
Non-Berwaldian Randers metrics of Douglas type on four-dimensional hypercomplex Lie groups
, 2017 In this paper we classify all non-Berwaldian Randers metrics of Douglas type arising from invariant hyper-Hermitian metrics on simply connected four-dimensional real Lie groups.
Hosseini, M., Moghaddam, H. R. Salimi
core
Aging and Cancer, EarlyView.This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha +4 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014 We calculated basic gauge-invariant tensors algebraically expressed through the matrix of conformal curvature. In particular, decomposition of the main tensor into gaugeinvariant irreducible summands consists of 4 terms, one of which is determined by ...
Leonid N Krivonosov +1 more
doaj +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source