Results 71 to 80 of about 464,650 (293)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On constant higher order mean curvature hypersurfaces in Hn×R ${\mathbb{H}}^{n}{\times}\mathbb{R}$
Advanced Nonlinear StudiesWe classify hypersurfaces with rotational symmetry and positive constant r-th mean curvature in Hn×R ${\mathbb{H}}^{n}{\times}\mathbb{R}$ . Specific constant higher order mean curvature hypersurfaces invariant under hyperbolic translation are also ...
Nelli Barbara +2 more
doaj +1 more source
Invariants over Curvature Tensor Fields
Journal of Algebra, 1998 The author presents a construction of higher degree polynomial \(O(n)\)-invariants over the space of curvature tensor fields. Let \({\mathcal C}\) be the space of the curvature tensors on the real \(n\)-dimensional space \(V\), endowed with a dot product \(g\) (the elements of \({\mathcal C}\) are \(4\)-linear forms on \(V\), having the usual ...
openaire +2 more sources
Cohomology of D-complex manifolds [PDF]
, 2012 In order to look for a well-behaved counterpart to Dolbeault cohomology in D-complex geometry, we study the de Rham cohomology of an almost D-complex manifold and its subgroups made up of the classes admitting invariant, respectively anti-invariant ...
Daniele Angella +4 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A Basic Inequality for the Tanaka-Webster Connection
Journal of Applied Mathematics, 2012 For submanifolds tangent to the structure vector field in Sasakian space forms, we establish a Chen's basic inequality between the main intrinsic invariants of the submanifold (namely, its pseudosectional curvature and pseudosectional curvature on one ...
Dae Ho Jin, Jae Won Lee
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Entropy, 2018 In this article, we consider statistical submanifolds of Kenmotsu statistical manifolds of constant ϕ-sectional curvature. For such submanifold, we investigate curvature properties. We establish some inequalities involving the normalized δ-Casorati
Simona Decu +3 more
doaj +1 more source
Heliyon, 2020 The contour of an arbitrary figure can be represented as a group of circles of curvature in contact with it, with each curvature circle represented by its center OC and radius r.
Susumu Kawakami +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source