Results 61 to 70 of about 201,081 (270)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

On constant higher order mean curvature hypersurfaces in Hn×R ${\mathbb{H}}^{n}{\times}\mathbb{R}$

Advanced Nonlinear Studies
We classify hypersurfaces with rotational symmetry and positive constant r-th mean curvature in Hn×R ${\mathbb{H}}^{n}{\times}\mathbb{R}$ . Specific constant higher order mean curvature hypersurfaces invariant under hyperbolic translation are also ...
Nelli Barbara, Pipoli Giuseppe, Russo Giovanni   +2 more
doaj   +1 more source

Partner Symmetries, Group Foliation and ASD Ricci-Flat Metrics without Killing Vectors

Symmetry, Integrability and Geometry: Methods and Applications, 2013
We demonstrate how a combination of our recently developed methods of partner symmetries, symmetry reduction in group parameters and a new version of the group foliation method can produce noninvariant solutions of complex Monge-Ampère equation (CMA) and
Andrei A. Malykh, Mikhail B. Sheftel
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Curvature Invariants of Statistical Submanifolds in Kenmotsu Statistical Manifolds of Constant ϕ-Sectional Curvature

Entropy, 2018
In this article, we consider statistical submanifolds of Kenmotsu statistical manifolds of constant ϕ-sectional curvature. For such submanifold, we investigate curvature properties. We establish some inequalities involving the normalized δ-Casorati
Simona Decu, Stefan Haesen, Leopold Verstraelen, Gabriel-Eduard Vîlcu   +3 more
doaj   +1 more source

The two definitions of the index difference [PDF]

, 2016
Given two metrics of positive scalar curvature metrics on a closed spin manifold, there is a secondary index invariant in real $K$-theory. There exist two definitions of this invariant, one of homotopical flavour, the other one defined by a index problem
Ebert, Johannes
core  

Q-Curvature, Spectral Invariants, and Representation Theory [PDF]

Symmetry, Integrability and Geometry: Methods and Applications, 2007
We give an introductory account of functional determinants of elliptic operators on manifolds and Polyakov-type formulas for their infinitesimal and finite conformal variations. We relate this to extremal problems and to the Q-curvature on even-dimensional conformal manifolds.
openaire   +5 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source