Results 191 to 200 of about 1,051,604 (281)

A single-particle analysis method for detecting membrane remodelling and curvature sensing.

J Cell Sci
Colussi A, Almeida-Souza L, McMahon HT.
europepmc   +2 more sources

Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A. [PDF]

Elife
Lincoff J, Helsell CVM, Marcoline FV, Natale AM, Grabe M.   +4 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Physics of Membrane Curvature Sensing by Proteins: Modeling and Simulations

Membrane curvature sensing is crucial for processes such as cell division and morphogenesis. Curvature sensing is also essential for subcellular functions such as membrane repair and the maintenance of organelles.
Badvaram Manjunath, Indrajit
core   +1 more source

Curvature sensing lipid dynamics in a mitochondrial inner membrane model. [PDF]

Commun Biol
Golla VK, Boyd KJ, May ER.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Amphipathic helical peptide-based fluorogenic probes for a marker-free analysis of exosomes based on membrane-curvature sensing. [PDF]

RSC Adv, 2020
Sato Y, Kuwahara K, Mogami K, Takahashi K, Nishizawa S.   +4 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Membrane Curvature Sensing by Amphipathic Helices [PDF]

Journal of Biological Chemistry, 2011
Martin Borch Jensen, Vikram Kjøller Bhatia, Christine C. Jao, Jakob Ewald Rasmussen, Søren L. Pedersen, Knud J. Jensen, Ralf Langen, Dimitrios Stamou   +7 more
openaire   +1 more source