Results 101 to 110 of about 480,873 (352)
Discrete Geometry from Quantum Walks
Condensed Matter, 2019 A particular family of Discrete Time Quantum Walks (DTQWs) simulating fermion propagation in 2D curved space-time is revisited. Usual continuous covariant derivatives and spin-connections are generalized into discrete covariant derivatives along the ...
Fabrice Debbasch
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
M\"obius and Laguerre geometry of Dupin Hypersurfaces
, 2015 In this paper we show that a Dupin hypersurface with constant M\"{o}bius curvatures is M\"{o}bius equivalent to either an isoparametric hypersurface in the sphere or a cone over an isoparametric hypersurface in a sphere.
Li, Tongzhu, Qing, Jie, Wang, Changping
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
AbstractThe notion of curvature is central to differential geometry and its numerous applications. The aim of this chapter is to offer a first introduction to curvature. Our main point is to explore how curvature connects to algebraic geometry. We start out with plane curves, and we then turn to more general real algebraic varieties.
Paul Breiding +2 more
+4 more sources
Lipid monolayer spontaneous curvatures: A collection of published values.
Chemistry and Physics of Lipids, 2021 Marcus K. Dymond
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source