Results 41 to 50 of about 28,286 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of Input Angle, Dimension Ratio-Mechanism Link to the Output, Transmission Angle and Motion Characteristic [PDF]

open access: yes, 2011
In the previous study, the design of a four bar linkage mechanism had been analyzed by using a constant length dimension of link. The relationship between degree inputs to degree output was generated by using mathematic model of generator function.
Sutikno, E. (Endi)   +1 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Disturbance optimization control of virtual synchronous generator based on improved fuzzy adaptive method

open access: yes电力工程技术
To address the issues of poor dynamic response and insufficient robustness in virtual synchronous generator (VSG) during grid connection, closing, or system disturbances, an improved fuzzy adaptive control strategy for VSG disturbance optimization is ...
Zhixiang WANG   +4 more
doaj   +1 more source

On mechanism design optimization for motion generation

open access: yes, 2007
A set of Burmester curves can represent an infinite number of planar four-bar motion generator solutions for a given series of prescribed rigid-body poses.
Russell, Kevin   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

风力发电机联轴器打滑力矩标定试验台设计开发

open access: yesJixie chuandong, 2014
A slip torque calibration test bed for wind generator shaft coupling which can simulate the actual working environment is designed and developed innovatively.Driven by the hydraulic oscillating cylinder,the wind generator shaft coupling is loaded by the ...
杨孟涛, 金红伟
doaj  

Experimental and modelling investigation of the deformation, drag and break-up of drizzle droplets subjected to strong aerodynamics forces in relation to SLD aircraft icing [PDF]

open access: yes, 2005
The distortion, drag and break-up of drizzle droplets subjected to strong aerodynamic forces was investigated to understand the pre-impact behaviour of droplets in aircraft icing from supercooled freezing drizzle.
Luxford, Geoffrey
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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