Results 41 to 50 of about 870 (217)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Un parcours d'écrivain au XXe siècle (Alexis Curvers et ses relations littéraires)
, 2006 En 1957, Tempo di Roma apporte le succès à Alexis Curvers, romancier belge (Liège 1906-1992). Ses admirateurs admettent mal que ce long chef-d œuvre soit son chant du cygne.
GRAVET, Catherine, HALEN, Pierre
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
E.F. Schmidt, M.N. Van Loon, H.H. Curvers, The Holmes Expedition to Luristan, 1989
, 1993 Potts Daniel T. E.F. Schmidt, M.N. Van Loon, H.H. Curvers, The Holmes Expedition to Luristan, 1989. In: Topoi, volume 3/1, 1993. pp.
Potts, Daniel T.
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Archeologisch bureau- en verkennend veldonderzoek, dmv boringen Lingsforterweg te Arcen (AM17402)
, 2019 Op 19 december 2017 is door Aeres Milieu een archeologisch bureau- en verkennend veldonderzoek d.m.v. boringen uitgevoerd aan de Lingsforterweg te Arcen, gemeente Venlo. Het doel van het verkennend veldonderzoek d.m.v.
Hagens, Drs. D. (Aeres milieu), ProjectLeader
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
O.M.C. Haex, H. H. Curvers and P.M.M. Akkermans (éd.), To the Euphrates and Beyond
, 1994 De Contenson Henri. O.M.C. Haex, H. H. Curvers and P.M.M. Akkermans (éd.), To the Euphrates and Beyond. In: Syria. Tome 71 fascicule 3-4, 1994. pp.
Contenson, Henri de
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source